
Breast Cancer Cell Growth and Death
An illustration comparing breast cancer cell apoptosis (top) and autophagy (bottom) during antiestrogen therapy. During apoptosis, antiestrogen drugs (yellow) compete with estrogen molecules to bind to the receptors. Meanwhile, inhibition of the autophagy gene ATG7 (orange) allows the apoptosis transcription factor IRF1 (blue) to program the cell to die during antiestrogen therapy. However when IRF1 levels decrease, ATG7 and autophagy factor BECN1 (purple) promote tumor growth and survival. Autolysosomes form during autophagy (bottom right) in the tumor cell to break down and recycle the cell's organelles for continued growth and survival.
Credit
Science Source
/ Evan Oto
Dimensions
4200 x 4200 pixels
Print Size @ 300 dpi
14 x 14 inches / 36 x 36 cm