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Illustration of chlorpromazine (thorazine), ball-and-stick molecular model. Chlorpromazine was one of the first antipsychotic drugs developed to treat schizophrenia and bipolar disorder. Chlorpromazine acts by blocking dopamine receptors in the brain. Chlorpromazine produces a calming effect and controls aggression, delusions and hallucinations. It is also prescribed to control nausea, vomiting and persistent hiccups.